Article of the Now
Learn the difference (sometimes called "Know the difference") is a both a meme and a piece of advice that you could probably make use of. Unlike most memes, learning the difference can potentially have full-life consequences that could save your life.
Thread of the Now
Two reddit lolcows join the forum to slapfight each other, everyone loses.
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From Encyclopædia Dramatica's endless supply of factoids: